Hirofumi Shoda Selected Research

Autoimmune Diseases (Autoimmune Disease)

9/2021	Fertility preservation in patients receiving gonadotoxic therapies for systemic autoimmune diseases in Japan.
8/2021	Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy.
1/2018	Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals.
7/2017	A case of refractory polyarteritis nodosa successfully treated with rituximab.
1/2017	Investigation of the pathogenesis of autoimmune diseases by iPS cells.
12/2016	Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.
3/2016	Immune responses to Mycobacterial heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis.
6/2015	A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity.
2/2015	TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
1/2012	[Autoantigen BiP and autoimmune diseases].

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Hirofumi Shoda Research Topics

Disease

21	Rheumatoid Arthritis 02/2022 - 01/2006
11	Autoimmune Diseases (Autoimmune Disease) 09/2021 - 12/2006
9	Arthritis (Polyarthritis) 04/2016 - 01/2006
8	Systemic Lupus Erythematosus (Libman-Sacks Disease) 10/2021 - 01/2011
7	Experimental Arthritis 04/2016 - 01/2006
3	Myositis (Idiopathic Inflammatory Myopathies) 01/2022 - 01/2020
3	Systemic Scleroderma (Systemic Sclerosis) 01/2022 - 01/2021
2	Inflammation (Inflammations) 07/2022 - 12/2016
2	Proteinuria 07/2022 - 01/2020
2	Muscle Weakness 01/2022 - 01/2020
2	Giant Cell Arteritis (Horton Disease) 01/2022 - 03/2014
2	Obesity 02/2021 - 01/2017
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 01/2021
2	Adult-Onset Still's Disease 01/2017 - 07/2011
1	Amyloidosis 07/2022
1	Chronic Kidney Failure (Chronic Renal Failure) 07/2022
1	Pain (Aches) 03/2022
1	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 03/2022
1	Ossification of the posterior longitudinal ligament of the spine 02/2022
1	Osteoarthritis 02/2022
1	Hearing Loss (Hearing Impairment) 02/2022
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2022
1	Polymyositis 01/2022
1	Myocarditis (Carditis) 01/2022
1	Camptocormia 01/2022
1	Muscular Diseases (Myopathy) 01/2022
1	Immunoglobulin G4-Related Disease 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Churg-Strauss Syndrome (Allergic Angiitis) 12/2021
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 10/2021
1	Acne Vulgaris 01/2021
1	Carcinoma (Carcinomatosis) 01/2021
1	Osteitis 01/2021
1	Rheumatic Diseases (Rheumatism) 01/2021
1	Synovitis 01/2021
1	Ulcer 01/2021
1	Vasculitis (Vasculitides) 01/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021
1	Hyperostosis 01/2021
1	Acquired Hyperostosis Syndrome (SAPHO Syndrome) 01/2021
1	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 01/2021
1	Lupus Nephritis 01/2020
1	Immune System Diseases (Immune Disorders) 03/2018

Drug/Important Bio-Agent (IBA)

6	CytokinesIBA 01/2022 - 07/2007
5	AntibodiesIBA 01/2022 - 01/2011
4	AutoantibodiesIBA 01/2022 - 01/2011
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2017 - 01/2006
4	AutoantigensIBA 03/2016 - 01/2012
3	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 12/2021 - 03/2015
3	Pharmaceutical PreparationsIBA 03/2018 - 01/2017
3	Interleukin-10 (Interleukin 10)IBA 01/2018 - 01/2012
3	Peptides (Polypeptides)IBA 06/2016 - 01/2011
3	acetyl 4-aminosalicylic acidIBA 04/2016 - 01/2011
3	Proteins (Proteins, Gene)FDA Link 03/2016 - 01/2011
3	Immunoglobulins (Immunoglobulin)IBA 03/2016 - 01/2011
2	GlucocorticoidsIBA 03/2022 - 01/2021
2	Creatine Kinase (Creatine Phosphokinase)IBA 01/2022 - 01/2020
2	Immunoglobulin G (IgG)IBA 01/2022 - 04/2016
2	Interleukin-17 (Interleukin 17)IBA 01/2022 - 11/2007
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2021 - 01/2021
2	Prednisolone (Predate)FDA LinkGeneric 01/2021 - 03/2014
2	Biological ProductsIBA 03/2018 - 12/2006
2	HLA-DRB1 Chains (HLA DRB1)IBA 01/2018 - 01/2016
2	EpitopesIBA 01/2018 - 05/2015
2	tocilizumab (atlizumab)FDA Link 01/2017 - 01/2016
2	Anti-Citrullinated Protein AntibodiesIBA 04/2016 - 08/2015
2	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 03/2016 - 01/2012
2	Protein-Arginine Deiminase Type 4IBA 01/2016 - 08/2015
2	Carrier Proteins (Binding Protein)IBA 01/2012 - 01/2011
1	canakinumab FDA Link 07/2022
1	Immunosuppressive Agents (Immunosuppressants)IBA 03/2022
1	2019-nCoV Vaccine mRNA-1273IBA 03/2022
1	Collagen Type XIIBA 02/2022
1	Antinuclear AntibodiesIBA 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	mepolizumabIBA 12/2021
1	Peroxidase (Myeloperoxidase)IBA 12/2021
1	VA 061 (VA061)IBA 10/2021
1	Inosine Triphosphate (ITP)IBA 10/2021
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 08/2021
1	Heparin (Liquaemin)FDA LinkGeneric 08/2021
1	AmphiregulinIBA 08/2021
1	EGF Family of ProteinsIBA 08/2021
1	Biomarkers (Surrogate Marker)IBA 08/2021
1	Epidermal Growth Factor (EGF)IBA 08/2021
1	Vitamin D FDA LinkGeneric 02/2021
1	LeptinIBA 02/2021
1	AdiponectinIBA 02/2021
1	AdipokinesIBA 02/2021
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2020
1	anti-dsDNA autoantibodyIBA 01/2020
1	Protein-Arginine DeiminasesIBA 01/2020
1	golimumab FDA Link 01/2020

Therapy/Procedure

5	Therapeutics 09/2021 - 07/2011
2	Oral Administration 03/2016 - 05/2015
1	Precision Medicine 10/2019